No signifiant correlation was present between blood groups and distribution of complicated cases, and between complicated falciparum cases and blood groups. This study was aimed at determining the prevalence of parasitaemia in blood donors and the association between blood group antigens and parasitaemia. Most subsaharan africans are duffy blood group negative because of. Association of abo blood group and plasmodium falciparum. Malaria clinical outcomes vary by erythrocyte characteristics, including abo blood group, but the effect of abo blood group on asymptomatic, uncomplicated and placental plasmodium falciparum p. It has long been known that people with blood type o. Association of the abo blood groups with falciparum. Of 17 blood group o malaria cases, 10 were having mild malaria while 05 had moderate and 02 had severe malaria. Abo blood groups and severity to plasmodium falciparum. This study therefore was to investigate plasmodium malaria and abo blood group among blood. We explored effects of abo blood group on asymptomatic, uncomplicated and placental falciparum.
Influence of abo blood groups in malaria infected pregnant. Whether blood group phenotypes are associated with risk of severe falciparum malaria in odisha, we analyzed 343 adult malaria patients. Pdf abo blood groups and malaria related clinical outcome. Some of these antigens are also present on the surface of other types of cells of.
Aborhesus blood group systems and malaria prevalence. There is also a hypothesis that plasmodium falciparum p. Cheesbrough m 2005 district laboratory manual for tropical countries. Correlation between h blood group antigen and plasmodium. There was low percentage of blood group o patients in the severe malaria category than in either uncomplicated malaria or healthy controls. This study was undertaken to investigate the abilities of different blood group erythrocytes to support in vitro growth of p. However, several studies undertaken have been unable to link abo blood groups to the incidence of malaria or to the repeat attacks of malaria 2,3. Plasmodium malaria and abo blood group among blood donors in. Persons may thus have type a, type b, type o, or type ab blood. Influence of abo blood groups in malaria infected pregnant women in enugu, southeast, nigeria. Falciparuminfected individuals were categorized as severe malaria and uncomplicated malaria. Some studies have suggested that abo blood groups have an impact on the.
In 200 malaria positive patients, blood group analysis was done. Malaria is a disease associated with high morbidity and mortality especially among children and other high risk groups. Pdf no association of phenotypic abo blood group and. Studies have reported association of abo blood group to resistance, susceptibility, and severity of p. In fact, group a is found in highest frequency in scandinavia, greenland, and the. Host genetic adaptations to plasmodium falciparum suggest new potential malaria treatment strategies. Some of these studies reported significant associations, suggesting that abo blood groups. B abo distributions among the cases severe or fatal malaria are significantly different from that observed in healthy adult ugandan blood donors. Determining the prevalence of malaria parasitaemia among asymptomatic individuals and its association with abo blood grouping could be a step to further studies to understand the immunity of malaria. The present findings indicate that individuals of blood groups a, b and ab are more susceptible to p. There has been growing evidence that abo blood group antigens influence susceptibility and resistance to parasitaemia. Although this therapy helps to save human lives, blood can nonetheless be a dreadful vehicle for the transmission of some infectious. Two drops of whole blood were placed in two different places of a greasefree clean glass slide on which a few drops of anti. In other reports, the abo blood group pattern differed even if blood group o was most common 19 20 21 cserti and dzik 22, a distribution pattern of blood group o followed by a is characteristic for african endemic for malaria.
However, other studies have reported variable associations between malaria infection and abo blood groups 12,19,21,26. Plasmodium falciparum rosetting, a parasite virulence phenotype associated with severe malaria, is reduced in blood group o erythrocytes compared with groups a, b, and ab, but the contribution of the abo blood group system to protection. A ll the manifestations of malarial illness are caused by the infection of the red blood cells by the asexual forms of the malaria parasite and the involvement of the red cells makes malaria a potentially multisystem disease, as every organ of the body is reached by the blood. Individuals with blood group a have been found to be highly susceptible to falciparum malaria whereas blood group. The most striking blood group association is of the duffy blood group with susceptibility to p.
Effect of abo blood group on asymptomatic, uncomplicated. These antigens may be proteins, carbohydrates, glycoproteins, or glycolipids, depending on the blood group system. Relationship between abo blood groups and malaria with. The abo blood group system is used to denote the presence of one, both, or neither of the a and b antigens on erythrocytes. The abo blood group and plasmodium falciparum malaria in awash, metehara and ziway areas, ethiopia. In clinical practice, abo is the most important system for blood group compatibility. Research article relative susceptibilities of abo blood. Recent studies of the pathogenesis of malaria have shown that parasite triggered red blood cell rosette formation is associated with the severity of clinical disease and malaria 4,5. The plasmodium parasite has established a close relationship between itself and. Determination of the various aborh blood group distributions and their association with malaria infection has paramount importance in the context of transfusion medicine and malaria control. Large numbers of severe malaria cases were also reported among blood group a individuals11. Relationship between abo blood groups and malaria with clinical. Of the 276 students examined for malaria infection, 27 were found positive 9. Among the uncomplicated malaria cases, 42 30% were of blood group a, 23 16.
Except for blood group ab individuals, of which none were infected, malaria infection did not vary among blood groups. Guidance manual abo and rh blood grouping document id no. A total of 2095 patients with fever were tested for malaria and classified according to abo blood groups. Blood group phenotypes a and b are risk factors for. Consequently, a high risk of transfusiontransmitted malaria persists. Thakur and verma8 in their study, concluded that abo blood groups do not show differentable 1. Prevalence of malaria parasitaemia and its association. The relationship between plasmodium falciparum and abo blood groups has been studied for many years.
Although the human genome has been remarkably altered by. Abo blood group, parasite rosetting and malaria susceptibility. Abo blood groups and secretor character in rheumatic carditis. A blood type also called a blood group is a classification of blood, based on the presence and absence of antibodies and inherited antigenic substances on the surface of red blood cells rbcs. Hence, there was a statistically significant relation between complicated mixed malaria cases and blood groups x. Silas a ufelle 1, kenechukwu c onyekwelu 2, joy e ikekpeazu 2, richard c ezeh 3, emmanuel a esom 4, uzoamaka a okoli2 1department of medical laboratory sciences, college of medicine, university of nigeria enugu campus, nigeria 2department of medical biochemistry, college of medicine, university. The link between abo blood groups and the incidence of malaria parasitaemia or immunity to malaria is still unclear akinboye and ogunrinade 1987. Among complicated mixed malaria cases, 4 cases had blood group a, 2 cases had blood group ab and 1 case had blood group o.
Research article assessing aborh blood group frequency. Abo blood group system, the classification of human blood based on the inherited properties of red blood cells erythrocytes as determined by the presence or absence of the antigens a and b, which are carried on the surface of the red cells. Pdf malaria infection and its relation to abo blood grouping. Table 6 shows distribution of abo blood group in relation to severity of malaria. The abo blood group system and plasmodium falciparum malaria. Pdf the study was conducted in a period from march to july 20 in 3 areas in sudan khartoum, al genaid and singa. The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the abo blood groups.
Occurrence of plasmodium falciparum malaria associated. Malaria parasitaemia was determined by microscopy of giemsastained. Sri lanka 12, mali 11, and ethiopia 1, while a significant association has also been. One such gene that is selected for by malaria is the abo blood group gene which has three alleles namely, a, b and o, coding for different types of agglutinogens attached to the surface of red blood cells rbcs and hence determining an individuals blood group. Abo blood groups and severity to plasmodium falciparum malaria infections barua p department of zoology, university of dhaka, bangladesh corresponding author. Facility based crosssectional study was conducted from february to june, 2015, to assess aborh blood groups distribution and their association with asymptomatic malaria. The results showed high prevalence of blood group b in both mild n 110 and. Research open access association of abo blood group with. How blood group o protects against malaria sciencedaily. Abo blood group, parasite rosetting and malaria susceptibility rosetting is characterized by the binding of p. Controls have a higher prevalence of group o, and cases have a higher prevalence of non. This parasite uses the duffy blood group antigen as the receptor to invade erythrocytes. We explored effects of abo blood group on asymptomatic, uncomplicated and placental falciparum infection in the published literature. Transmission of malaria by blood transfusion remains a significant public health problem in the malaria endemic regions like ghana.
Nevertheless, further in depth studies are required to clearly establish the role that abo blood group plays in p. There is increasing evidence that plasmodium falciparum malaria is influenced by abo blood group but the extent of association between both is yet to be well defined. A total of 29 human blood group systems are now recognized by the. Of the 276 students examined for malaria infection, 27 were. This is the first observation of an association between the abo blood type and covid19. Pdf plasmodium malaria and abo blood group among blood. Abo blood group system an overview sciencedirect topics. Transmission of malaria by blood transfusion remains a significant public health problem in the malaria endemic regions like nigeria. Plasmodium falciparum rosetting, a parasite virulence phenotype associated with severe malaria, is reduced in blood group o erythrocytes compared with groups a, b, and ab, but the contribution of the abo blood group system to protection against severe malaria has received little attention. A mismatch very rare in modern medicine in this, or any other serotype, can cause a potentially fatal adverse reaction after a.
In the other blood groups, it was observed that groups mnss. Certain abo blood group is thought to be protective of severe malaria. Assessing aborh blood group frequency and association. In human blood transfusions it is the most important of the 36 different blood type or group classification systems currently recognized. The abo blood group and plasmodium falciparum malaria in. They support the hypothesis that otype alleles have been evolutionarily selected in areas with high incidences of malarial infection and suggest that rifins may contribute to the varying global distribution of abo blood groups by selecting preferentially for group o.
Malaria is a common transfusiontransmissible infection. There is increasing evidence that the abo blood group phenotypes modulates plasmodium falciparum rosetting and may influence the clinical manifestation of severe malaria. The abo blood group system is the most important blood group system in clinical practice. Association of asymptomatic malaria and abo blood group.
Pdf plasmodium parasitaemia and blood groups among blood. Seven cases of mixed malaria had blood group a and o. In the indian scenario, the literature relating to malaria and the blood groups are sparse and have mixed results. A total of 269 febrile outpatients who visited dore bafeno health center, southern ethiopia, were examined for malaria and also tested for abo blood groups in. Is there a relation between abo blood group and malaria. The abo blood groups consist of a, b and h carbohydrate antigens which can regulate protein activities during infection and antibodies against these antigens. Pdf association of asymptomatic malaria and abo blood. Percentage distribution of the abo blood group types in the three study categories of the 70 blood samples examined in the severe malaria category, there were 25 35. No significant differences were found between the presence of malaria infection and abo antigens. The abo blood group system is arguably the best known, and yet the most functionally mysterious, genetic polymorphism in humans. Group o is the most common blood group in turkey and persia. Relationship between the abo blood group and the covid19. The results showed that blood group a was associated with a higher risk for acquiring covid19 compared with nona blood groups, whereas blood group o was associated with a lower risk for the infection compared with nono blood groups.
A number of studies were conducted to investigate the association between abo blood group system and some disease conditions. In the century since the discovery of the abo blood groups, numerous associations between abo groups and disease have been noted. Abo blood groups and malaria related clinical outcome. The prevalence of malaria parasitaemia and predisposition. Relationship between malaria and abo blood group types. Severe malaria was further clinically phenotyped into cerebral malaria, noncerebral severe malaria and multiorgan dysfunction. There were apparent discrepancies and contradictions in the. Malaria has been a major selective force on the human population, and several erythrocyte polymorphisms have evolved that confer resistance to severe malaria.
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